Main challenges in Programme area according to EUSAIR are low competitiveness on international markets of SMEs, the effectiveness of the innovation activities, human skills capacities, lack of support schemes and weak involvement of stakeholders and interrelation of business, research and the public sector in sectors of blue economy. To tackle these challenges, INNOVAMARE project aim is to enhance framework conditions on cross-border level by jointly develop and implement strategical and operational level capacity that consist of mix of policy instruments and innovation players as a frame for development of innovative technologies for sustainability of Adriatic Sea. Project is set up on mission-oriented approach that rather than focusing on sectors – as in traditional industrial policy – mission-oriented policy focuses on problem-specific societal challenges, which many different sectors interact to solve. In this case the project focusing on using mix of policy instruments together with innovation players to increase effectiveness of innovation activities of underwater robotics and sensors in direction of sustainability of Adriatic sea as a crucial strategical societal challenge on cross-border level.